Water → Benzyl 2-amino-6-(2-furyl)-9H-purine-9-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Triethylamine	HCID 8471	—
Reactant	Benzyl chloroformate	HCID 10387	—
Reactant	6-(furan-2-yl)-9H-purin-2-amine	HCID 178508247	—
Catalyst	4-(Dimethylamino)pyridine	HCID 14284	—
Solvent	Dimethylformamide	HCID 6228	—
Product	Benzyl 2-amino-6-(2-furyl)-9H-purine-9-carboxylate	HCID 9923784	98%

Reaction Conditions

Temperature	5 °C

Reaction Steps

A solution of 6-(2-furyl)-1H-purine-2-amine (0.201 g, 1.0 mmol), benzyl chloroformate (0.20 mL, 1.1 mmol), triethylamine (0.21 mL, 1.5 mmol) and DMAP (15 mg) in DMF (10 mL) was stirred at room temperature for 4 h, poured into cold water, cooled for 30 min at 5° C. and the resulting solid filtered and dried at 40° C. to give the title compound (0.327 g, 98%) as a cream solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07452894B2
Source dataset	uspto-grants-2008_11
ORD ID	ord-7d90aa1fec9a467fa1b64addc4c84360
Source note	uspto-grants-2008_11