HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 44449695, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Benzene, 1-(bromomethyl)-3-nitro- | HCID 77568 | — |
| Reactant | 6-(furan-2-yl)-9H-purin-2-amine | HCID 178508247 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 44449695 | HCID 44449695 | 60% |
Reaction Steps
An ice-cold solution of 6-(2-furyl)1H-purine-2-amine (201 mg, 1 mmol) in DMF (6 mL) was treated with NaH (44 mg, 1.1 mmol), stirred for 30 min, treated with 3-nitrobenzyl bromide (238 mg, 1.1 mmol), stirred at room temperature for 3 h, treated with water and the resulting solid filtered, suspended in methanol, stilled for 30 min, and filtered to give the title compound (201 mg, 60%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452894B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-cbbeee01ba0f4c9298235283b0213d2f |
| Source note | uspto-grants-2008_11 |