反应详情

An ice-cold solution of 9-(3-aminobenzyl)-6-(2-furyl)-9H-purine-2-amine (145 mg, 0.48 mmol) in pyridine (3 mL) was treated with acetyl chloride (38 μL, 0.53 mmol), stirred for 1 h, quenched with water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo and purified by chromatography (SiO2: Hexane:EtOAc (1:3) to EtOAc:MeOH (99:1)) to give the title compound (71 mg, 43%) as a yellow solid.

1. customquenched with water
2. extractionextracted with EtOAc
3. dry with materialdried (MgSO4)
4. concentrationconcentrated in vacuo
5. custompurified by chromatography (SiO2: Hexane:EtOAc (1:3) to EtOAc:MeOH (99:1))