Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroacetone | HCID 6571 | — |
| Reactant | HCID 86592467 | HCID 86592467 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 10268835 | HCID 10268835 | 12% |
Reaction Steps
A stirred suspension of 2-amino-9-(2-fluorobenzyl)-9H-purine-6-thiocarboxamide (200 mg, 0.5 mmol) and chloroacetone (1 mL) in isopropanol (5 mL) was heated at 80° C. for 2 h, filtered and the filtrate concentrated in vacuo and purified by chromatography [SiO2; EtOAc] to give the title compound (26 mg, 12%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07452894B2 |
|---|
| Source dataset | uspto-grants-2008_11 |
|---|
| ORD ID | ord-3ab887f0074d45d194dcbf59724a4052 |
|---|
| Source note | uspto-grants-2008_11 |
|---|
