反应详情

To a mixture of adefovir (1.36 g, 5 mmol) and 3-hexadecyloxy-1-propanol (1.8 g, 6 mmol) in dry pyridine was added DCC (2.06 g, 10 mmol). The mixture was heated to reflux and stirred 18 h then cooled and filtered. The filtrate was concentrated under reduced pressure and the residue was applied to a short column of silica gel. Elution of the column with 9:1 dichloromethane/methanol yielded hexadecyloxypropyl-adefovir (HDP-ADV) as a white powder.

1. temperatureThe mixture was heated
2. temperatureto reflux
3. temperaturethen cooled
4. filtrationfiltered
5. concentrationThe filtrate was concentrated under reduced pressure
6. washElution of the column with 9:1 dichloromethane/methanol