HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → (S)-ethyl 2-(tert-butoxycarbonylamino)-3-(4-nitrophenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-Dimethylaminopyridine | HCID 21885 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine | HCID 7021882 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-ethyl 2-(tert-butoxycarbonylamino)-3-(4-nitrophenyl)propanoate | HCID 10593086 | — |
Reaction Steps
5 g of Boc-Phe(4-NO2)-OH, 3.09 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 5 ml of ethanol and 2 g of dimethylaminopyridine were stirred in dichloromethane for 3 days. The obtained substance was washed with 1N hydrochloric acid, an aqueous solution of saturated sodium hydrogen carbonate and saturated NaCl solution, and dried with magnesium sulfate. The solvent was removed to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452905B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-15b45a522c8e48c7bbda57da8c517cf0 |
| Source note | uspto-grants-2008_11 |