HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Ammonium Hydroxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-Azido-2-fluorocyclohexyl 2-phenylethyl ether | HCID 72574144 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | [3-Fluoro-4-(2-phenylethoxy)cyclohexyl]amine | HCID 69276156 | — |
Reaction Steps
To an ethyl acetate (80 mL) solution of 4-Azido-2-fluorocyclohexyl 2-phenylethyl ether (0.677 g, 2.57 mmol) was added 10% palladium on carbon (0.200 g). The resulting mixture was hydrogenated using a balloon. After 1 h the contents of the reaction flask were filtered through Celite® and the filtrate evaporated under reduced pressure. Flash column chromatography (methylene chloride:methanol:ammonium hydroxide, 90:10:1) gave [3-Fluoro-4-(2-phenylethoxy)cyclohexyl]amine as a waxy oil (0.519 g, 85% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452893B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-55e5248c1ccf43db90af744311a51c78 |
| Source note | uspto-grants-2008_11 |