benzyl tert-butyl ((1S,3S)-cyclopentane-1,3-diyl)dicarbamate → tert-Butyl N-((1S,3S)-3-aminocyclopentyl)carbamate

Participants

Reaction Steps

A mixture of benzyl tert-butyl (1S,3S)-cyclopentane-1,3-diylbiscarbamate (2.02 g, 6.04 mmol) and 10% Pd/C (142 mg) in EtOH (200 mL) was shaken on a Parr apparatus under hydrogen (36 psi) for 1 hr. The reaction mixture was filtered through celite and concentrated to give the title compound (1.37 g) as an opaque paste.

Provenance & Evidence