Methyl iodide → 1-(7,8-Bis(4-chlorophenyl)-2-methyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide

HRID 271430Notes

Reaction equation

HRID 271430 reaction equation
ClC1C=CC(C2N=C(N3CC(NCC)(C(N)=O)C3)N3C(=O)NN=C3C=2C2C=CC(Cl)=CC=2)=CC=1.IC.[Cl:37][C:38]1[CH:43]=[CH:42][C:41]([C:44]2[N:49]=[C:48]([N:50]3[CH2:53][C:52]([NH:57][CH2:58][CH3:59])([C:54]([NH2:56])=[O:55])[CH2:51]3)[N:47]3[C:60](=[O:65])[N:61]([CH2:63]C)[N:62]=[C:46]3[C:45]=2[C:66]2[CH:71]=[CH:70][C:69]([Cl:72])=[CH:68][CH:67]=2)=[CH:40][CH:39]=1>>[Cl:37][C:38]1[CH:39]=[CH:40][C:41]([C:44]2[N:49]=[C:48]([N:50]3[CH2:53][C:52]([NH:57][CH2:58][CH3:59])([C:54]([NH2:56])=[O:55])[CH2:51]3)[N:47]3[C:60](=[O:65])[N:61]([CH3:63])[N:62]=[C:46]3[C:45]=2[C:66]2[CH:67]=[CH:68][C:69]([Cl:72])=[CH:70][CH:71]=2)=[CH:42][CH:43]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 159530981-(7,8-Bis(4-chlorophenyl)-2-ethyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamideHCID 587728451-(7,8-Bis(4-chlorophenyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide

Product 1

HCID 159530991-(7,8-Bis(4-chlorophenyl)-2-methyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide

Procedure

The title compound was prepared by coupling 1-(7,8-bis(4-chlorophenyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide with iodomethane in a manner analogous to that in which 1-(7,8-bis(4-chlorophenyl)-2-ethyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide was prepared. HPLC/MS: retention time 3.318 min, [M+H]30 =512.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-8a9507c134da4a0fb43f64df1ae2bc19
Source dataset
uspto-grants-2008_11
Patent number
US07452892B2

Reaction notes

Loading…