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Chloride → 7,8-bis(4-chlorophenyl)-2-ethyl-5-(pyridin-2-ylmethylamino)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloride | HCID 312 | — |
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | 1-(7,8-Bis(4-chlorophenyl)-2-ethyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide | HCID 15953098 | — |
| 反応物 | 5-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one | HCID 58772840 | — |
| 生成物 | 7,8-bis(4-chlorophenyl)-2-ethyl-5-(pyridin-2-ylmethylamino)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one | HCID 15953194 | — |
反応手順
The title compound was prepared in two steps from 5-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one by nucleophilic displacement of chloride with the requisite amine, followed by alkylation with iodoethane, in a manner analogous to that in which 1-(7,8-bis(4-chlorophenyl)-2-ethyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide was prepared. HPLC/MS: retention time=3.623 min, [M+H]30 =491.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07452892B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-5a9c18c8247a4b58a2d92636237376f0 |
| 出典メモ | uspto-grants-2008_11 |