Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloride → 5-(azetidin-1-yl)-7,8-bis(4-chlorophenyl)-2-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloride | HCID 312 | — |
| 반응물 | Iodoethane | HCID 6340 | — |
| 반응물 | 1-(7,8-Bis(4-chlorophenyl)-2-ethyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide | HCID 15953098 | — |
| 반응물 | 5-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one | HCID 58772840 | — |
| 생성물 | 5-(azetidin-1-yl)-7,8-bis(4-chlorophenyl)-2-ethyl-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one | HCID 15953243 | — |
반응 단계
The title compound was prepared in two steps from 5-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one by nucleophilic displacement of chloride with the requisite amine, followed by alkylation with iodoethane, in a manner analogous to that in which 1-(7,8-bis(4-chlorophenyl)-2-ethyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide was prepared. HPLC/MS: retention time=4.423 min, [M+H]30 =440.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07452892B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-86e7a85d29044ae897a144df4a5fd95b |
| 출처 메모 | uspto-grants-2008_11 |