HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → HCID 15953280, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | 1-(7,8-Bis(4-chlorophenyl)-2-ethyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide | HCID 15953098 | — |
| Reactant | 5-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one | HCID 58772840 | — |
| Product | HCID 15953280 | HCID 15953280 | — |
Reaction Steps
The title compound was prepared in two steps from 5-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one by nucleophilic displacement of chloride with the requisite amine, followed by alkylation with iodoethane, in a manner analogous to that in which 1-(7,8-bis(4-chlorophenyl)-2-ethyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)-3-(ethylamino)azetidine-3-carboxamide was prepared. HPLC/MS: retention time=4.173 min, [M+H]30 =456.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452892B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-e334d8bedb4e4544a98240276bac68e0 |
| Source note | uspto-grants-2008_11 |