3-(Bromomethyl)pyridine hydrobromide → 3-(2-Methyl-1-pyridin-3-ylmethyl-1H-imidazol-4-ylethynyl)-benzonitrile

HRID 271488Notes

Reaction equation

HRID 271488 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[N:6]=1.Br.Br[CH2:19][C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1>>[CH3:1][C:2]1[N:3]([CH2:19][C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[N:6]=1

Participants

3

Reactant 2

HCID 127070373-(Bromomethyl)pyridine hydrobromideHCID 178432699HCID 178432699, compound

Product 1

HCID 672468663-(2-Methyl-1-pyridin-3-ylmethyl-1H-imidazol-4-ylethynyl)-benzonitrile

Procedure

The title compound, MS: m/e=299.2 (M+H30), was prepared in accordance with the general method of example 1 from 3-(2-methyl-1H-imidazol-4-ylethynyl)-benzonitrile and 3-(bromomethyl)pyridine hydrobromide.

Sources & evidence

ORD record
ord-b4eb9088a9634f00884c13af0b4791f4
Source dataset
uspto-grants-2008_11
Patent number
US07452909B2

Reaction notes

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