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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 271491Generated: October 31, 2026

3-Chloro-5-(chloromethyl)pyridine hydrochloride → 4-[1-(2-Chloro-pyridin-5-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine

https://huagongshe.com/reaction/271491

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloro-5-(chloromethyl)pyridine hydrochlorideHCID 67246305—
ReactantHCID 178418884HCID 178418884—
Product4-[1-(2-Chloro-pyridin-5-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridineHCID 11324744—

Reaction Steps

The title compound, MS: m/e=323.2 (M+H30), was prepared in accordance with the general method of example 1 from 2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 3-chloro-5-chloromethyl-pyridine hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07452909B2
Source datasetuspto-grants-2008_11
ORD IDord-fc53be558e9f4bf38119e09dd6a700fc
Source noteuspto-grants-2008_11