Ethanol → HCID 136355249, compound

Participants

Reaction Steps

The product of Step 2 (180 mg, 0.4 mmol) in ethanol (4 ml) containing aqueous hydroxylamine (2 ml, 50% in water) was heated under reflux for 1 hour. After cooling to room temperature, the mixture was concentrated in vacuo and the residue co-evaporated with ethanol (3×5 ml). The residue was purified by silica gel chromatography eluting with a 0.1:1:20 mixture of 0.880 ammonia solution:ethanol:chloroform to give the title compound (100 mg, 64%); MS(ES+) m/e 390 [M+H]+.

Provenance & Evidence