Ethyl Acetate → HCID 86760763, compound

Participants

Reaction Steps

A mixture of the products from Step 2 (0.6 g, 1.62 mmol) and Description 1 Step 2 (0.367 g, 1.8 mmol) in toluene (10 ml) was treated with bis(triphenylphosphine) palladium (II) chloride (0.113 g, 0.162 mmol) and 2M aqueous sodium carbonate (0.2 ml, 3.93 mmol) and heated under reflux for 18 hours. After cooling to room temperature, the mixture was poured into ethyl acetate, washed with saturated aqueous sodium bicarbonate solution and brine, dried and reduced in vacuo. The crude title compound (0.310 g) was used in the next step without further purification; MS(ES+) m/e 449 [M+H]+.

Provenance & Evidence