Hydroxylamine → 5-(5-Hydroxymethyl-2-pyridin-4-yl-furan-3-yl)indan-1-one oxime

Participants

Reaction Steps

The product of Step 3 (150 mg, (0.49 mmol) was heated at reflux in ethanol (10 ml) containing 50% aqueous hydroxylamine (1 ml) for 2 hours. The solution was concentrated in vacuo to an oil and purified by silica gel chromatography eluting with 1:9:90.880 ammonia:ethanol:dichloromethane to afford the title product (128 mg, 81%); MS(ES+) m/e 321 [M+H]+.

Provenance & Evidence