Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Benzene, 1-fluoro-2-methyl-4-nitro- | HCID 68001 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 2967785 | HCID 2967785 | 85% |
Reaction Steps
A suspension of piperazine (3.0 mmol), N,N-diisopropylethylamine (6.0 mmol), and 2-fluoro-5-nitrotoluene (7.5 mmol) in acetonitrile are stirred at 50° C. for 3 h and then 100° C. for 9.5 h, and poured into water. The mixture is extracted with AcOEt. The organic layer is washed with water, dried over magnesium sulfate, and concentrated. The crude product is purified by silica gel column chromatography to give the product in 85% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07452886B2 |
|---|
| Source dataset | uspto-grants-2008_11 |
|---|
| ORD ID | ord-bcef5b1a55d54000bb5ed829e6ecf442 |
|---|
| Source note | uspto-grants-2008_11 |
|---|
