HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Dimethyl-[2-(4-pyridin-4-yl-phenoxy)-ethyl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Chloro-N,N-dimethylethylamine | HCID 7901 | — |
| Reactant | 4-(Pyridin-4-yl)phenol | HCID 135410177 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Dimethyl-[2-(4-pyridin-4-yl-phenoxy)-ethyl]-amine | HCID 17968254 | — |
Reaction Steps
1 g of 4-pyridin-4-yl-phenol, 1.3 g of (2-chloro-ethyl)-dimethyl-amine.HCl and 2.42 g of K2CO2 were heated for 48 h under reflux. The mixture was diluted with chloroform, washed with brine and dried over MgSO4. After evaporation to dryness the residue was chromatographed on silicagel with CH2Cl2/MeOH/NH3conc=90:10:1 to give dimethyl-[2-(4-pyridin-4-yl-phenoxy)-ethyl]-amine as brown powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452886B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-703704d54f9647a6aaaf8fef7329dd72 |
| Source note | uspto-grants-2008_11 |