Methanol → HCID 59834720, compound

Participants

Reaction Steps

1-Ethyl-piperazine (1.1 mmol) and 6-(4-bromomethyl-benzyl)-7-(2,2-dimethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile (0.35 mmol) are dissolved in DMF (3 ml) and stirred at room temperature for 3 h. After the reaction mixture is diluted with AcOEt, the organic layer is washed with brine, dried over magnesium sulfate and filtrated. The solvent is evaporated and the residue is purified by chromatography on silica gel using 2% MeOH in CH2Cl2 and 7% MeOH in CH2Cl2. The solvent of the latter effluent is removed by evaporation and dried in vacuo to afford crystals. yield 81.8%, Rf=0.34 (CH2Cl2:MeOH=9:1).

Provenance & Evidence