HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 271626Generated: November 1, 2026
Phosphorus oxychloride → 2-chloro-9-(2,2-dimethyl-propyl)-8-methyl-9H-purine
https://huagongshe.com/reaction/271626
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | 2-Chloro-N4-(2,2-dimethylpropyl)-4,5-pyrimidinediamine | HCID 17968210 | — |
| Product | 2-chloro-9-(2,2-dimethyl-propyl)-8-methyl-9H-purine | HCID 17968266 | — |
Reaction Steps
To a solution of 4.2 g of 2-chloro-N4-(2,2-dimethyl-propyl)-pyrimidine-4,5-diamine in 40 ml of DMA was added 1.6 ml of POCl3. The solution was stirred at 100° C. for 2 hours, cooled and extracted with ethyl acetate and saturated NaHCO3 solution. The organic phases were dried over sodium sulfate and evaporated to dryness yielding 2-chloro-9-(2,2-dimethyl-propyl)-8-methyl-9H-purine as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07452886B2 |
|---|
| Source dataset | uspto-grants-2008_11 |
|---|
| ORD ID | ord-b5863ba0d3594366bba27b279bff0551 |
|---|
| Source note | uspto-grants-2008_11 |
|---|
