Trifluoroacetic acid → HCID 58625002, compound

Participants

Reaction Steps

A solution of 0.9 g (2.5 mmol) of 1,3-oxazolane-2-one 7 in 25 ml (0.325 mol) of CF3COOH was stirred at ˜25° C. for 3-3.5 hours. The solvent was evaporated under vacuum and the residue was crystallized from ethanol. The yield was 0.63 g of oxazole 8 (73%), Tmelt=103-104° C. The results found (%): C, 62.43; H, 5.62; S, 18.78. C18H19NO2S2. The results calculated (%): C, 62.58; H, 5.54; S, 18.56. 1H NMR spectrum (DMSO-d6, δ, ppm): 1.99 (s, 3H, CH3); 2.12 (s, 3H, CH3); 2.27 (s, 3H, CH3); 2.32 (s, 3H, CH3); 4.03 (d, 2H, CH2, J=6 Hz); 4.93 (d, 1H, CH, J=17 Hz); 5.09 (d, 1H, CH, J=10 Hz); 5.73 (m, 1H, CH); 6.37 (s, 1H, CH); 6.74 (s, 1H, CH).

Provenance & Evidence