5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10251593, compound

HRID 271646Notes

Reaction equation

HRID 271646 reaction equation
[F:1][C:2]1[CH:15]=[C:14](I)[CH:13]=[CH:12][C:3]=1[O:4][CH2:5][CH2:6][N:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[CH:31])=[N:28][CH:29]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:25]=[CH:26][C:27]([C:30]#[C:31][C:14]3[CH:13]=[CH:12][C:3]([O:4][CH2:5][CH2:6][N:7]4[CH2:11][CH2:10][CH2:9][CH2:8]4)=[C:2]([F:1])[CH:15]=3)=[N:28][CH:29]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 67364141HCID 67364141, compound

Product 1

HCID 10251593HCID 10251593, compound

Procedure

Prepared according to general working method I from 1-[2-(2-fluoro-4-iodo-phenoxy)-ethyl]-pyrrolidine (300 mg, 0.90 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (201 mg, 0.94 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-846af9c81d9341338491fea428497475
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

Loading…