5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10367021, compound

HRID 271647Notes

Reaction equation

HRID 271647 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([O:12][CH2:13][CH2:14][N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]#[CH:34])=[N:31][CH:32]=2)=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]#[C:34][C:2]3[CH:3]=[CH:4][C:5]([O:12][CH2:13][CH2:14][N:15]4[CH2:19][CH2:18][CH2:17][CH2:16]4)=[C:6]([CH:11]=3)[C:7]([O:9][CH3:10])=[O:8])=[N:31][CH:32]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69079616HCID 69079616, compound

Product 1

HCID 10367021HCID 10367021, compound

Procedure

Prepared according to general working method I from methyl 5-iodo-2-(2-pyrrolidin-1-yl-ethoxy)-benzoate (3.0 g, 8.0 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (1.76 g, 8.24 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1968a3d70cc54a63b9be3d535be1fdda
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

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