5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10096944, compound

HRID 271650Notes

Reaction equation

HRID 271650 reaction equation
I[C:2]1[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[C:4]([O:16][C:17]([F:20])([F:19])[F:18])[CH:3]=1.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:29]=[CH:30][C:31]([C:34]#[CH:35])=[N:32][CH:33]=2)=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[CH:29]=[CH:30][C:31]([C:34]#[C:35][C:2]3[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]4[CH2:13][CH2:12][CH2:11][CH2:10]4)=[C:4]([O:16][C:17]([F:20])([F:19])[F:18])[CH:3]=3)=[N:32][CH:33]=2)=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69077563HCID 69077563, compound

Product 1

HCID 10096944HCID 10096944, compound

Procedure

Prepared according to general working method I from 1-[2-(4-iodo-2-trifluoromethoxy-phenoxy)-ethyl]-pyrrolidine (250 mg, 0.62 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (140 mg, 0.65 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8eab612ef72846b5abcbb714dcb71692
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

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