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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 271654Generated: November 3, 2026

5-(4-Chloro-phenyl)-2-ethynyl-pyridine → 5-(4-Chloro-phenyl)-2-[3-(2-pyrrolidin-1-yl-ethoxy)-phenylethynyl]-pyridine

https://huagongshe.com/reaction/271654

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 57845328—
ReactantHCID 60772709HCID 60772709—
Product5-(4-Chloro-phenyl)-2-[3-(2-pyrrolidin-1-yl-ethoxy)-phenylethynyl]-pyridineHCID 10069717—

Reaction Steps

Prepared according to general working method I from 1-[2-(3-iodo-phenoxy)-ethyl]-pyrrolidine (119 mg, 0.37 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (80 mg, 0.37 mmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07452911B2
Source datasetuspto-grants-2008_11
ORD IDord-aa12e5ac6a334f60a469742b78e69f23
Source noteuspto-grants-2008_11