5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10254336, compound

HRID 271657Notes

Reaction equation

HRID 271657 reaction equation
I[C:2]1[CH:3]=[C:4]([CH3:20])[C:5]([O:12][CH2:13][CH2:14][N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:29]=[CH:30][C:31]([C:34]#[CH:35])=[N:32][CH:33]=2)=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[CH:29]=[CH:30][C:31]([C:34]#[C:35][C:2]3[CH:3]=[C:4]([CH3:20])[C:5]([O:12][CH2:13][CH2:14][N:15]4[CH2:19][CH2:18][CH2:17][CH2:16]4)=[C:6]([CH:11]=3)[C:7]([O:9][CH3:10])=[O:8])=[N:32][CH:33]=2)=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69075591HCID 69075591, compound

Product 1

HCID 10254336HCID 10254336, compound

Procedure

Prepared according to general working method I from methyl 5-iodo-3-methyl-2-(2-pyrrolidin-1-yl-ethoxy)-benzoate (150 mg, 0.39 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (112 mg, 0.53 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bf8c8771d7bf424ba4274cd6300be918
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

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