5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10092545, compound

HRID 271659Notes

Reaction equation

HRID 271659 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][N:11]([CH3:15])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[CH:30])=[N:27][CH:28]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[C:30][C:2]3[CH:3]=[CH:4][C:5]([N:8]4[CH2:14][CH2:13][CH2:12][N:11]([CH3:15])[CH2:10][CH2:9]4)=[N:6][CH:7]=3)=[N:27][CH:28]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69079695HCID 69079695, compound

Product 1

HCID 10092545HCID 10092545, compound

Procedure

Prepared according to general working method I from 1-(5-iodo-pyridin-2-yl)-4-methyl-[1,4]diazepan (237 mg, 0.75 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (161 mg, 0.75 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ee28615be0c646d1a0527cee765bea1c
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

Loading…