5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10385640, compound

HRID 271660Notes

Reaction equation

HRID 271660 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:23]=[CH:24][C:25]([C:28]#[CH:29])=[N:26][CH:27]=2)=[CH:18][CH:17]=1>>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:23]=[CH:24][C:25]([C:28]#[C:29][C:2]3[CH:3]=[CH:4][C:5]([N:8]4[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]4)=[N:6][CH:7]=3)=[N:26][CH:27]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69075989HCID 69075989, compound

Product 1

HCID 10385640HCID 10385640, compound

Procedure

Prepared according to general working method I from 1-(5-iodo-pyridin-2-yl)-4-methyl-piperazine (235 mg, 0.78 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (167 mg, 0.78 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d27ea9fcfd4342ef8cb3aa0a499d1031
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

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