5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10095615, compound

HRID 271671Notes

Reaction equation

HRID 271671 reaction equation
I[C:2]1[CH:19]=[CH:18][C:5]2[N:6]([CH2:11][CH2:12][N:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)[C:7](=[O:10])[N:8]([CH3:9])[C:4]=2[CH:3]=1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]#[CH:34])=[N:31][CH:32]=2)=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]#[C:34][C:2]3[CH:19]=[CH:18][C:5]4[N:6]([CH2:11][CH2:12][N:13]5[CH2:17][CH2:16][CH2:15][CH2:14]5)[C:7](=[O:10])[N:8]([CH3:9])[C:4]=4[CH:3]=3)=[N:31][CH:32]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69080210HCID 69080210, compound

Product 1

HCID 10095615HCID 10095615, compound

Procedure

Prepared according to general working method I from 5-iodo-3-methyl-1-(2-pyrrolidin-1-yl-ethyl)-1,3-dihydro-benzimidazol-2-one (120 mg, 0.32 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (68 mg, 0.32 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6809e690f191453ab9450407a7f7b2a8
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

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