5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 10049588, compound

HRID 271680Notes

Reaction equation

HRID 271680 reaction equation
I[C:2]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]#[CH:34])=[N:31][CH:32]=2)=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]#[C:34][C:2]3[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][N:15]4[CH2:19][CH2:18][CH2:17][CH2:16]4)=[C:8]4[C:3]=3[CH:4]=[CH:5][CH:6]=[N:7]4)=[N:31][CH:32]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69071542HCID 69071542, compound

Product 1

HCID 10049588HCID 10049588, compound

Procedure

Prepared according to general working method I from 5-iodo-8-(2-pyrrolidin-1-yl-ethoxy)-quinoline (200 mg, 0.54 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (116 mg, 0.54 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-846a81267da34461b37fbc441dae971b
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

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