5-(4-Chlorophenyl)-2-ethynyl-3-fluoropyridine → HCID 59835780, compound

HRID 271709Notes

Reaction equation

HRID 271709 reaction equation
I[C:2]1[CH:17]=[CH:16][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([CH3:15])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:26]=[C:27]([F:33])[C:28]([C:31]#[CH:32])=[N:29][CH:30]=2)=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:26]=[C:27]([F:33])[C:28]([C:31]#[C:32][C:2]3[CH:17]=[CH:16][C:5]([O:6][CH2:7][CH2:8][N:9]4[CH2:14][CH2:13][CH:12]([CH3:15])[CH2:11][CH2:10]4)=[CH:4][CH:3]=3)=[N:29][CH:30]=2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 600554165-(4-Chlorophenyl)-2-ethynyl-3-fluoropyridineHCID 690610171-(2-(4-Iodophenoxy)ethyl)-4-methylpiperidine

Product 1

HCID 59835780HCID 59835780, compound

Procedure

Prepared according to general working method I from 1-[2-(4-iodo-phenoxy)-ethyl]-4-methyl-piperidine (164 mg, 0.48 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-3-fluoro-pyridine (110 mg, 0.48 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ef06bc067d544d70acb87652cb352287
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

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