5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 59835919, compound

HRID 271718Notes

Reaction equation

HRID 271718 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[CH:30])=[N:27][CH:28]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]#[C:30][C:2]3[CH:7]=[CH:6][C:5]([C:8]#[C:9][CH2:10][N:11]4[CH2:15][CH2:14][CH2:13][CH2:12]4)=[CH:4][CH:3]=3)=[N:27][CH:28]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69076021HCID 69076021, compound

Product 1

HCID 59835919HCID 59835919, compound

Procedure

Prepared according to general working method I from 1-[3-(4-iodo-phenyl)-prop-2-ynyl]-pyrrolidine (230 mg, 75%, 0.55 mmol) and 5-(4-chloro-phenyl)-2-ethynyl-pyridine (118 mg, 0.55 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e658d76abd14403b8f31a498b1af6d98
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Reaction notes

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