Bromine → 2-(2-Bromopropionyl)-4-nitrothiophene

HRID 27176Notes

Reaction equation

HRID 27176 reaction equation
[C:1]([C:5]1[S:6][CH:7]=[C:8]([N+:10]([O-:12])=[O:11])[CH:9]=1)(=[O:4])[CH2:2][CH3:3].[Br:13]Br>C(Cl)Cl>[Br:13][CH:2]([CH3:3])[C:1]([C:5]1[S:6][CH:7]=[C:8]([N+:10]([O-:12])=[O:11])[CH:9]=1)=[O:4]

Participants

4

Reactant 2

HCID 24408BromineHCID 128138611-(4-Nitro-2-thienyl)-1-propanone

Product 1

HCID 233436772-(2-Bromopropionyl)-4-nitrothiophene

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the procedure of Example 12B, using 9.26 g. of 2-propionyl-4-nitrothiophene and 7.99 g. of bromine in 100 ml. of methylene chloride, there is obtained 13.0 g. of product m.p. 79°-82° C. which is recrystallized from ethanol affording 2-(2-bromopropionyl)-4-nitrothiophene m.p. 82.5°-83° C.

Workup

  1. customof product m.p. 79°-82° C. which is recrystallized from ethanol

Sources & evidence

ORD record
ord-7b1dec319b184782955d50971d67a7bd
Source dataset
uspto-grants-1980_09
Patent number
US04220654

Reaction notes

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