Cyclohexylamine → HCID 566644, compound

HRID 271839Notes

Reaction equation

HRID 271839 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:8]1(=O)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>C1C=CC=CC=1>[CH:1]1([N:7]=[C:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 7967Cyclohexanone

Product 1

HCID 566644HCID 566644, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
80 °C

Procedure

Cyclohexylamine Compound 20a (4.64 g, 46.50 mmol) was added to a solution of cyclohexanone Compound 2a (4.0 g, 46.50 mmol) in benzene (100 mL) at ambient temperature under a N2 atmosphere. The mixture was refluxed at 80° C. for 5 hours, using a Dean Stark apparatus for the removal of water, and concentrated to dryness. The crude product was purified by distillation at aspirator pressure to afford cyclohexyl-cyclohexylidene-amine Compound 20b (7.33 g, 88%) as a clear oil.

Workup

  1. customfor the removal of water
  2. concentrationconcentrated to dryness
  3. distillationThe crude product was purified by distillation at aspirator pressure

Sources & evidence

ORD record
ord-15011846e1114d04a4581a95bab98560
Source dataset
uspto-grants-2008_11
Patent number
US07452997B2

Reaction notes

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