Cyclooctanone → HCID 4147876, compound

HRID 271841Notes

Reaction equation

[C:1]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:10]([O:14][C:15]([NH:17][NH2:18])=[O:16])([CH3:13])([CH3:12])[CH3:11]>>[C:10]([O:14][C:15]([NH:17][N:18]=[C:1]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:16])([CH3:13])([CH3:12])[CH3:11]

Participants

Reactant 2

HCID 10403Cyclooctanone

HCID 70091tert-Butyl carbazate

Product 1

HCID 4147876HCID 4147876, compound

Procedure

According to a published procedure, cyclooctanone Compound 21a was reacted with hydrazinecarboxylic acid tert-butyl ester to produce an intermediate N′-cyclooctylidene-hydrazinecarboxylic acid tert-butyl ester Compound 21b (as described in Ghali N K and Venton D L, J. Org. Chem., 1981, 46, 5413). According to the published procedure, Compound 21b was carried forward to provide cyclooctyl-hydrazine hydrochloride Compound 21c.

Sources & evidence

ORD record: ord-48c2f26e57e84e6a988c00282b31932c
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07452997B2

Reaction notes

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