Lithium Hydroxide → (S)-2-(2-benzoylphenylamino)-3-(3'-methylaminobiphenyl-4-yl)propionic acid

Participants

Reaction Steps

In a manner similar to the preparation of the (S)-2-(2-benzoylphenylamino)-3-[3′-(3-heptyl-1-methylureido)biphenyl-4-yl]propionic acid (Example 2), using 1.2 g (1.06 mmol) of ethyl (S)-2-(2-benzoylphenyl-amino)-3-(3′-methylaminobiphenyl-4-yl)propionate (Example 1g) and 120 mg (2.85 mmol) of lithium hydroxide, 0.90 g of acid is obtained with an 80% yield.

Provenance & Evidence