HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-piperidinecarboxylate → (S)-1-{2-(2-benzoylphenylamino)-3-[3'-(3-heptyl-1-methylureido)biphenyl-4-yl]propionyl}piperidine-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | (S)-2-(2-benzoylphenylamino)-3-[3'-(3-heptyl-1-methylureido)biphenyl-4-yl)propionic acid | HCID 10483579 | — |
| Product | (S)-1-{2-(2-benzoylphenylamino)-3-[3'-(3-heptyl-1-methylureido)biphenyl-4-yl]propionyl}piperidine-4-carboxylic acid ethyl ester | HCID 10010169 | 107.7% |
Reaction Steps
In a similar manner, using 20 mg (33.8 μmol) of the (S)-2-(2-benzoylphenylamino)-3-[3′-(3-heptyl-1-methylureido)biphenyl-4-yl]propionic acid (Example 2) and 4.8 mg (30.5 μmol) of ethyl piperidine-4-carboxylate, 24 mg of expected product are obtained with a quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452878B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-adf664b9e95d471ba98ba3c74d900e6e |
| Source note | uspto-grants-2008_11 |