HRID271850

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)[C@H](Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1)NC(=O)OC(C)(C)C

HCID10789275

未命名化合物

结构：CCOC(=O)[C@H](Cc1ccc(-c2cccc(NCC(=O)OC(C)(C)C)c2)cc1)NC(=O)OC(C)(C)C

HCID86601620

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)[C@H](Cc1ccc(-c2cccc(C=O)c2)cc1)NC(=O)OC(C)(C)C

HCID86601619

未命名化合物

收率 61%

PROCEDURE

实验过程

In a manner similar to the preparation of ethyl (S)-2-tert-butoxycarbonylamino-3-[3′-(tert-butoxycarbonylmethylamino)biphenyl-4-yl]propionate (Example 1e), using 173 g (391 mmol) of ethyl (S)-2-tert-butoxycarbonylamino-3-(4-trifluoromethanesulfonyloxyphenyl)propionate and 82 g (547 mmol) of 3-boronic acid-benzaldehyde, 95.7 g of coupled product are isolated with a 61% yield.

WORKUP

后处理

customare isolated with a 61% yield