Ethyl 2-oxocyclohexanecarboxylate → ethyl (S)-2-(2-{3'-[(benzoylmethylamino)methyl]biphenyl-4-yl}-1-ethoxycarbonylethylamino)-benzoate

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Reaction Steps

In a manner similar to the preparation of the ethyl (S)-2-(2-benzoylphenylamino)-3-(3′-methylaminobiphenyl-4-yl)propionate (Example 1 g), using 6.7 g (16.1 mmol) of ethyl (S)-2-amino-3-{3′-[(benzoylmethyl-amino)methyl]biphenyl-4-yl}propionate (Example 28f) and 3 ml (19.3 mmol) of ethyl 2-oxocyclohexanecarboxylate, 0.90 g of ethyl (S)-2-(2-{3′-[(benzoylmethylamino)methyl]biphenyl-4-yl}-1-ethoxycarbonylethylamino)-benzoate is isolated with a 10% yield.

Provenance & Evidence