Acetyl chloride → N-(3',4'-dichlorophenyl)-3,4-dimethyl-2-acetoxy-5-oxo-2,5-dihydropyrrole

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Reaction Steps

27.2 g of N-(3',4'-dichlorophenyl-3,4-dimethyl-2-hydroxy-5-oxo-2,5-dihydropyrrole (see Example 3) is refluxed together with 20.7 g of K2CO3 in 150 ml of methyl ethyl ketone. After cooling, there is added dropwise 8.2 g of acetyl chloride, with the temperature of the reaction mixture rising from 15° to 35°. The reaction mixture is filtered after 24 hours, and the filtrate is concentrated by evaporation. The residue is recrystallised from methanol to give 23.9 g (76% of theory) of the above product in the form of colourless crystals, m.p. 109°-110°.

Provenance & Evidence