HCID 68417816, compound → HCID 68420017, compound

HRID 271863Notes

Reaction equation

[C:1]([CH2:9][NH:10][CH2:11][C:12]1[CH:13]=[C:14]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][C@H:25]([NH:30][C:31]([CH3:41])=[CH:32][C:33](=[O:40])[C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:26]([O:28][CH3:29])=[O:27])=[CH:20][CH:19]=2)[CH:15]=[CH:16][CH:17]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC(CC1C=CC(C2C=CC=C(CNCC(=O)C3C=CC=CC=3)C=2)=CC=1)C(OC)=O>>[C:1]([CH2:9][NH:10][CH2:11][C:12]1[CH:13]=[C:14]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][CH:25]([NH:30][C:31]([CH3:41])=[CH:32][C:33](=[O:40])[C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:26]([O:28][CH3:29])=[O:27])=[CH:20][CH:19]=2)[CH:15]=[CH:16][CH:17]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 68417816HCID 68417816, compound

HCID 68418820HCID 68418820, compound

Product 1

HCID 68420017HCID 68420017, compoundYield 66%

Procedure

In a manner similar to the preparation of the methyl (S)-3-{3′-[(benzoylmethylamino)methyl]biphenyl-4-yl}-2-(1-methyl-3-oxo-3-phenylpropenylamino)propionate (Example 31b), using 500 mg (1.24 mmol) of methyl 2-amino-3-{3′-[(benzoylmethylamino)methyl]biphenyl-4-yl}propionate, 450 mg of expected product is obtained with a 66% yield.

Sources & evidence

ORD record: ord-c20ad297d9cc4e17b119b0a29f5155be
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07452878B2

Reaction notes

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