HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxo-1-(1-benzylpiperidin-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyrazine → HCID 22293278, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxo-1-(1-benzylpiperidin-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyrazine | HCID 22293263 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22293278 | HCID 22293278 | 124.4% |
Reaction Steps
2-Oxo-1-(1-benzylpiperidin-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyrazine (1.7 g, 5.5 mmol) was dissolved in methanol (100 mL) and hydrogenated over 20% palladium on carbon (0.5 g) at 55 psi hydrogen overnight. The catalyst was filtered and solvent evaporated to give the title compound (1.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452903B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-5bde5b77d10b418591ff3320128112af |
| Source note | uspto-grants-2008_11 |