Trifluoroacetic acid → Trifluoroacetic acid

HRID 271941Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 271941
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C@H:9]1[CH2:15][N:14]([CH2:16][C:17]([OH:20])([CH3:19])[CH3:18])[C:13](=[O:21])[C@H:12]([N:22](C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)[CH2:11][CH2:10]1.[F:37][C:38]([F:43])([F:42])[C:39]([OH:41])=[O:40]>C(Cl)Cl>[NH2:22][C@@H:12]1[CH2:11][CH2:10][C@@H:9]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=2[F:1])[CH2:15][N:14]([CH2:16][C:17]([OH:20])([CH3:18])[CH3:19])[C:13]1=[O:21].[C:39]([OH:41])([C:38]([F:43])([F:42])[F:37])=[O:40]

Komponenten

5

Edukt 2

HCID 6422Trifluoroacetic acidHCID 21114341Di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate

Produkt 2

HCID 6422Trifluoroacetic acidHCID 60037871(3R,6S)-3-Amino-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)azepan-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-2-oxoazepan-3-yl]imidodicarbonate (0.095 g, 0.185 mmol) in DCM (10 mL) was treated with trifluoroacetic acid (3 mL). After 1 h the reaction was concentrated to dryness to afford the title compound as a TFA salt. MS 313.2 (M+1).

Aufarbeitung

  1. concentrationAfter 1 h the reaction was concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-61fdd8d050f447e29fc17e133a444bf8
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07452903B2

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