Dimethyl Sulfoxide → HCID 86603599, compound

Participants

Reaction Conditions

Reaction Steps

To a 0° C. solution of N-(tert-butyl)-4-chloro-2-fluoro-5-{[6-(2-hydroxyethyl)-6-phenyl-1,3-oxazinan-3-yl]carbonyl}benzenesulfonamide (25.2 mg, 0.05 mmol) in dimethyl sulfoxide (71 μL, 1 mmol), diisopropylethylamine (53 μL, 0.30 mmol) and 1 mL CH2Cl2 was added SO3.pyr in one portion. The reaction mixture was stirred for 2 h at 0° C., saturated aqueous NaHCO3 was added, and the aqueous layer was extracted with CHCl3. After evaporation, the resultant crude N-(tert-butyl)-4-chloro-2-fluoro-5-{[6-(2-oxoethyl)-6-phenyl-1,3-oxazinan-3-yl]carbonyl}benzenesulfonamide was obtained and used in the next step without further purification.

Provenance & Evidence