HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 272050Generated: October 31, 2026
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 11712792, compound
https://huagongshe.com/reaction/272050
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 1-(2-(Dimethylamino)ethyl)piperazine | HCID 2736229 | — |
| Reactant | HCID 59836116 | HCID 59836116 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 11712792 | HCID 11712792 | 17.7% |
Reaction Steps
To a mixture of 3-[7-(2-Methoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-benzoic acid (35 mg, 0.1 mmol), EDCI (77 mg, 0.40 mmol), HBTU (3.8 mg, 0.01 mmol) and diisopropylethylamine (175 μl, 1.0 mmol) in DMF (1 mL) was added 2-(dimethylamino)ethylpiperzine (55 μl, 0.3 mmol). The mixture was stirred at 70° C. for 5 hours before the solvents were removed. The resulting yellow oil was washed with water, dissolved in DMSO and purified on reverse phase HPLC to afford the title compound (8.6 mg, 12% over 2 steps) as yellow solid. MS: m/z 485.2 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07452993B2 |
|---|
| Source dataset | uspto-grants-2008_11 |
|---|
| ORD ID | ord-43832ec4bda64845b29dd80e8058af6d |
|---|
| Source note | uspto-grants-2008_11 |
|---|
