Allyl bromide → HCID 69100724, compound

HRID 272092Notes

Reaction equation

HRID 272092 reaction equation
[CH2:1]([N:4]1[CH2:9][CH2:8][CH2:7][C@H:6]([CH2:10][NH:11][C:12]([C@H:14]2[CH2:18][CH2:17][CH2:16][N:15]2[C:19]([C@@H:21]2[CH2:25][C@@H:24]([OH:26])[CH2:23][N:22]2[C:27](=[O:48])[CH2:28][C:29]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:20])=[O:13])[CH2:5]1)[CH:2]=[CH2:3].[CH2:49]([Br:52])[CH:50]=[CH2:51]>>[Br-:52].[CH2:1]([N+:4]1([CH2:51][CH:50]=[CH2:49])[CH2:9][CH2:8][CH2:7][C@H:6]([CH2:10][NH:11][C:12]([C@H:14]2[CH2:18][CH2:17][CH2:16][N:15]2[C:19]([C@@H:21]2[CH2:25][C@@H:24]([OH:26])[CH2:23][N:22]2[C:27](=[O:48])[CH2:28][C:29]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)=[O:20])=[O:13])[CH2:5]1)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 7841Allyl bromideHCID 69101508HCID 69101508, compound

Product 1

HCID 69100724HCID 69100724, compound

Procedure

The title compound was prepared by a method similar to Example 128, using (2R)-N-{((3R)-1-allyl-3-piperidyl)methyl}-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonyl-pyrrolidine-2-carboxamide and allyl bromide. The compound was obtained as a white foamy substance.

Workup

  1. customThe compound was obtained as a white foamy substance

Sources & evidence

ORD record
ord-7fc8254c87d04f48924ae9ea23611e29
Source dataset
uspto-grants-2008_11
Patent number
US07452908B2

Reaction notes

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