HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Chrysin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5,7-Dimethoxyflavone | HCID 88881 | — |
| Reactant | HCID 72557682 | HCID 72557682 | — |
| Product | Chrysin | HCID 5281607 | — |
Reaction Steps
Condensation with [4-(2-chlorocarbonyl-phenoxy)-but-2-enyl]-phosphonic acid diethyl ester (synthesis below) is followed by successive treatment with sodium hydride, hydrochloric acid and sodium carbonate, generating the 5,7-dimethoxyflavone. Demethylation to provide the 5,7-dihydroxyflavone final product is achieved as in Scheme 27.2 (see Bioorg. Med. Chem. Lett., (2000), 10, 1037).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07452901B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-cde793510ed54f1cb3e10ba7b305f589 |
| Source note | uspto-grants-2008_11 |