Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → 3-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-6-(3-pyridylmethyl)-1,2,4-triazin-5-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole | HCID 665568 | — |
| 반응물 | 3-Methylthio-6-(3-pyridylmethyl)-1,2,4-triazin-5-one | HCID 135755424 | — |
| 생성물 | 3-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-6-(3-pyridylmethyl)-1,2,4-triazin-5-one | HCID 135703178 | 70.9% |
반응 단계
3-Methylthio-6-(3-pyridylmethyl)-1,2,4-triazin-5-one (2.34 g) and 2-(5-methyl-4-imidazolylmethylthio)ethylamine (1.88 g) were heated together on anoil bath (160°-70°). The cooled mixture was triturated with boiling methanol and the solid was recrystallised from dimethylformamide to give the title compound as a colourless solid (2.53 g) m.p. 232°14 233°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04220767 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-6b437eb8e10d40d187944d5fb7c72424 |
| 출처 메모 | uspto-grants-1980_09 |