HCID 178505054, compound → HCID 178505061, compound

Participants

Reaction Steps

A mixture of 0.16 g of trans-N-[5-[((2S)-3-{benzyl[4-(1,1′-biphenyl-4-yl)cyclohexyl]amino}-2-hydroxypropyl)oxy]-2-(benzyloxy)phenyl]methanesulfonamide (0.23 mmol) and of 0.1 g of 10% palladium-on-charcoal (50% in water) in ethanol (6 ml) is placed under a hydrogen atmosphere and stirred for 4 hours. The reaction mixture is filtered through celite. The solvents are evaporated under reduced pressure and trans-N-{5-[((2S)-3-{[4-(1,1′-biphenyl-4-yl)cyclohexyl]amino}-2-hydroxypropyl)oxy]-2-hydroxyphenyl}methanesulfonamide is obtained in the form of a white solid (0.08 g, 68%) after purification on silica gel (eluent: dichloromethane/methanol, 99/1 to 85/15 gradient in 30 minutes).

Provenance & Evidence